AEM Accepts, published online ahead of print on 30 October 2009

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Appl. Environ. Microbiol. doi:10.1128/AEM.01553-09
Copyright (c) 2009, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Maltose improves Glucose Utilization in Corynebacterium glutamicum: Application for the Improvement of L-Valine Productivity

Felix S. Krause, Alexander Henrich, Bastian Blombach, Reinhard Krämer, Bernhard J. Eikmanns, and Gerd M. Seibold^*

Institute of Microbiology and Biotechnology, University of Ulm, D-89069 Ulm, Germany; Institute of Biochemistry, University of Cologne, D-50674 Cologne, Germany

^* To whom correspondence should be addressed. Email: gerd.seibold{at}uni-koeln.de.

Corynebacterium glutamicum efficiently utilizes maltose as a substrate. We here show that the presence of maltose increases glucose utilization by rising expression of ptsG, encoding the glucose-specific EII of the phosphotransferase system. Consequently, L-valine productivity of a pyruvate dehydrogenase complex-deficient C. glutamicum strain was improved in the presence of maltose.