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Appl. Environ. Microbiol. doi:10.1128/AEM.00893-08
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Escherichia coli constructs expressing human or porcine enterotoxins induce an identical diarrheal disease in a piglet infection model

The Center for Infectious Disease Research & Vaccinology, Department of Veterinary Science, South Dakota State University, Brookings, SD; Dept. of Diagnostic Medicine Pathobiology, Kansas State University, Manhattan, KS

^* To whom correspondence should be addressed. Email: weiping.zhang{at}sdstate.edu.

	Abstract

To develop a piglet model for studying diarrhea disease and developing vaccines, we challenged gnotobiotic piglets with isogenic E. coli strains constructed to express porcine 987P(F6) fimbriae and a heat-labile or a heat-stable enterotoxin to examine clinical outcomes. Piglets developed identical diarrheal disease when inoculated with constructs expressing human or porcine enterotoxins.