This Article Full Text (PDF) Other Versions of this Article: AEM.00067-08v1 74/17/5583    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Google Scholar Articles by Söderberg, M. A. Articles by Cianciotto, N. P. PubMed PubMed Citation Articles by Söderberg, M. A. Articles by Cianciotto, N. P. Agricola Articles by Söderberg, M. A. Articles by Cianciotto, N. P.

 Previous Article  |  Next Article 

Appl. Environ. Microbiol. doi:10.1128/AEM.00067-08
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

The Importance of Type II Secretion for Legionella pneumophila Survival in Tap Water and Amoebae at Low Temperature

Department of Microbiology and Immunology, Northwestern University Medical School, Chicago, Illinois 60611

^* To whom correspondence should be addressed. Email: n-cianciotto{at}northwestern.edu.

	Abstract

Legionella pneumophila type II secretion mutants showed reduced survival in both tap water at 4-17°C and aquatic amoebae at 22-25°C. Wild-type supernatants stimulated growth of these mutants, indicating secreted factors promote low-temperature survival. There was a correlation between low-temperature survival and secretion function when twelve additional Legionella species were examined.